Bak-like단백질을 code하는 cDNA의 동정

• 영문명: Identification of Bak-like Protein cDNA
• 발행기관: 대한약학회
• 저자명: 김진경(Jin Kyeoung Kim)
• 간행물 정보: 『약학회지』제45권 제4호 (2001년), 426~430쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.08.31

영문 초록

Cells are eliminated in a variety of physiological settings by apoptosis, a genetically encoded process of cellular suicide. Bak, a member of the Bcl-2 protein fami1y; accelerates apoptosis by an unknown mechanism. We have found a novel cDNA encoding a 101 amino acid protein possessing a Bak-like in our full-length cDNA bank. Bak-like shares the conserved domains BHI and 2 with other proapoptotic proteins but lacks the BH3 domain. Bak-like is expressed in a wide variety of tissues. Like Bak, Bak-like gene product primarily enhances apoptotic cell death following an appropriate stimulus.

키워드

Human cDNA bank apoptosis Bak-like alternative splicing variants.