진세노사이드 Rh2의 방향선택적 합성

• 영문명: Regioselective Synthesis of Ginsenoside Rh2
• 발행기관: 대한약학회
• 저자명: 신명희(Myoung Hee Shin) 정지형(Jee H. Jung) 장은하(Eun Ha Chang) 임광식(Kwang Sik Im)
• 간행물 정보: 『약학회지』제45권 제4호 (2001년), 328~333쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2001.08.31

영문 초록

Ginsenoside Rh2, a minor glycoside constituent of the red ginseng is known as an unique antitumor compound. Several attempts to prepare it in a large scale including semisynthesis from bettalafolientriol, an 3-epimer of 20(S)-protopanaxadiol, has been reported. We have previously reported a synthesis of ginsenoside Rh2 from 20(S)-protopanaxadiol obtained by alkaline hydrolysis of total ginsenoside. The regioselective synthesis of this compound was achieved by protection of 12-OH group.

키워드

Regioselective protection 20(5)-protopanaxadiol ginsenoside Rh2 glycosylation.