벤조펜안드리딘과 관련된 알칼로이드의 합성

• 영문명: Synthesis of Benzophenanthridine-Related Alkaloids
• 발행기관: 대한약학회
• 저자명: 김신규(Sin Kyu Kim) 이형원(Hyung Won Lee) 김인종(In Jong Kim) 이마세(Ma Se Lee)
• 간행물 정보: 『약학회지』제36권 제3호 (1992년), 250~254쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.06.29

영문 초록

Benzo[C]phenanthidine alkaloids were found to exhibit considerably strong antileukemic activies. These alkaloids have been shown to be biosynthesized from the corresponding alkaloids throung an oxidative C6-N bond cleavage followed by recyclization between C6 and C13 position of the protoberberine. Recently we have achieved the biomimetic transformation of protoberberine alkaloid, berberine into benzo[C]phenanthridine alkaloid, chelerythrine.