혈액중 지페프롤의 가스크로마토그래피에 의한 분석

• 영문명: Cas Chromatographic Analysis of Zipeprol in Blood
• 발행기관: 대한약학회
• 저자명: 유영찬(Young Chan Yoo) 정희선(Hee Sun Chung) 김은미(Eung Mi Kim)
• 간행물 정보: 『약학회지』제36권 제3호 (1992년), 191~198쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.06.29

영문 초록

The abuse of zipeprol, an antitussive agent, is prevalent among young people. Ten fatal cases of zipeprol concentration in blood after its abuse had caused death are disscussed. GC equipped with TSD was used to quantify the drug in postmortem blood and GC/MS to identify the metabolites in urine after preliminary test. The calibration curve of zipeprol was linear (r = 0.998) and the recoveries of zipeprol 5, 10 and 20mcg added to 1ml postmortem blood were 97.2 +/- 3.9, 92.5 +/- 3.9 and 86.9 +/- 4.6% respectively. The blood zipeprol concentration varied 2.9 to 24.69 mcg/ml in 10 fatal cases. All the deaths were young adults with the age of 16-21. Three metabolites were identified in drug abuser''s urine, 2-methoxy-2-phenyl ethylpiperazine, 2-hydroxy-3-methoxy-3-phenyl propylpiperazine and a demethylated zipeprol.