인체 뇨중의 숙신산 독실아민의 대사체

• 영문명: Metabolites of Doxylamine succinate in Human Urine
• 발행기관: 대한약학회
• 저자명: 엄기동(Khee Dong Eom) 정병화(Byung Hwa Jung) 정봉철(Bong Chul Chung) William Slikker Jr 박종세(Jong Sei Park)
• 간행물 정보: 『약학회지』제36권 제3호 (1992년), 230~240쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.06.29

영문 초록

The metabolic profile of doxylamine, N,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy] ethanamine, was determined in the human urine. The free fractions of extracts were obtained without hydrolysis, and the conjugated fractions of extracts were obtained with enzyme hydrolysis using beta-glucuronidase/arylsulfatase from Helix pomatia. The mixture of acetic anhydride/pyridine (10 : 1, v : v) was used to derivatize the urinary extracts and then analyzed by gas chromatography and mass selective detector. N-desmethyldoxylamine, doxylamine carboxylic acid, desaminohydroxydoxylamine, N, N-didesmethyldoxylamine, N-acetyl conjugates of N-desmethyl and N, N-didesmethyldoxylamine, quarternary ammonium N-glucuronide of doxylamine, N-desmethyldoxylamine N-glucuronide and unchanged doxylamine were detected in the human urine obtained after oral treatment with doxylamine succinate. N-methyl-alpha-hydroxy-2-[1-phenyl-1-(2-pyridinyl)ethoxy] ethanamine, which can be a key intermediate of this metabolism, was tentatively identified by the interpretation of its mass spectrum. In this study, we proposed the metabolic pathway of doxylamine in the human on the basis of our data of the identified metabolites of doxylamine.