원자흡광광도법에 의한 리팜피신의 정량에 관한 연구

• 영문명: Studies on the Determination of Rifampicin by Atomic Absorption Spectrophotometry
• 발행기관: 대한약학회
• 저자명: 이왕규(Wang Kyu Lee) 김박광(Bak Kwang Kim) 유병기(Byung Ki Ryu)
• 간행물 정보: 『약학회지』제29권 제4호 (1985년), 220~222쪽, 전체 3쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1985.08.31

영문 초록

Rifampicin reacts with cupric ion to produce rifampicin-Cu(II) chelate (2:1) at pH 6.5, which can be extracted with methylisobutylketone (MIBK). Therefore, rifampicin can be quantitatively determined by measuring the quantity of Cu(II) in the organic phase by atomic absorption spectrophotometry. Because higher absorbance ratio was obtained in pH 6.0~7.0, buffer solution at pH 6.5 was used in this measurement. Linear relationship was found between absorbance and concentration in the range of 1.0~4.O X 10-4M. This method might be applicable to the determination of rifampicin in the preparations.