중추성 항고혈압약이 뇌내 신경전달물질의 생합성 효소에 미치는 영향

• 영문명: The Effect of Centrally Active Antihypertensive Agent on Biosynthetic Enzyme Activity of Neurotransmitter in Brain
• 발행기관: 대한약학회
• 저자명: 윤재순(Jae Soon Yun)
• 간행물 정보: 『약학회지』제29권 제4호 (1985년), 165~175쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1985.08.31

영문 초록

It has been reported that clonidine is alpha2-adrenergic agonist, potent new hypotensive drug in human with low dose. The change in blood pressure is implicated in the concentration, release, uptake and metabolism of catecholamine and activity of catecholamine synthesizing enzyme in specific brain areas. Thus the experiment was set up to investigate the effect on the enzyme activity of clonidine alone and that of clonidine pretreated with imipramine or tranylcypromine by measuring activity of the Dopa-forming enzyme, tyrosine hydroxylase (TH) and epinephrine forming enzyme, phenylethanolamine-N-methyl transferase (PNMT) in brain and adrenal gland. The TH activity in brainstem and substantia nigra is decreased by intraperitoneally administered clonidine 0.1mg/kg twice a day for 5 days, but increased in the rats pretreated with imipramine 10mg/kg intraperitoneally given 26 hrs and 5 hrs before decaptitation. However the TH activity in all regions of brain is increased in rats pretreated with tranylcypromine 10mg/kg intraperitoneally twice a day for 5 days. The effect of clonidine on TH activity is due to inhibition release of norepinephrine by activation of presynaptic alpha2-adrenoreceptor, axon terminal result in the decrease of TH activity in brain. The increasing of TH activity in brain results in attenuation of the role of clonidine by pretreated with imipramine or tranylcypromine in rats. The activity of PNMT was not significantly affected by clonidine, imipramine and tranylcypromine in adrenal gland.