간흡충에 대하여 구충작용을 갖는 Diarylbutane류의 합성

• 영문명: Synthesis of the Anthelmintic Diaryl Butanes against Clonorchis sinensis
• 발행기관: 대한약학회
• 저자명: 주정숙(Jeong Suk Joo) 류성호(Sung Ho Ryu) 유병태(Beong Tae Yoo) 백병걸(Byeung Kirl Baek) 이재구(Jae Ku Rhee) 안병준(Byung Zun Ahn)
• 간행물 정보: 『약학회지』제29권 제4호 (1985년), 183~187쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1985.08.31

영문 초록

During investigation of the anthelmintic substances against Clonorchis sinensis which are based on the structure of meso-dihydroguairaretic acid, some non-mesoic diaryl butanes were synthesized by Grignard reaction and their anthelmintic activities were determined. In this reaction, an aryl butanone was reacted with benzylmagnesium chloride to produce the corresponding diaryl hydroxybutane which was converted to the corresponding diaryl butane by zinc and hydrogen chloride. The substituents in benzene ring of the diaryl butanes were changed by methylation or demethylation. Among the synthesized substances, 4-phenyl-1-(3,4-dihydroxyphenyl)-2,3-dimethylbutane(VII), 4-phenyl-1-(3-hydroxy-4-methoxyphenyl)-2,3-dimethylbutane(IX) and 4-phenyl-1-(4-hydroxy-3-methoxyphenyl)-2,3-dimethylbutane(VI) showed strong wormicidal effects against Clonorchis sinensis in that order. Phenolic hydroxyl group seemed to play a certain role for the wormicidal activity of the diaryl butanes.