갈근 부탄올 엑기스가 흰쥐에 유발된 카드뮴 독성에 미치는 영향

• 영문명: Pharmacological Effects of Puerariae Radix Butanol Extract on Cadmium Toxicity in Rats.
• 발행기관: 대한약학회
• 저자명: 손동헌(Dong Hun Sohn) 안형수(Hyung Soo Ann) 신승덕(Seung Duk Shin)
• 간행물 정보: 『약학회지』제29권 제4호 (1985년), 206~215쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1985.08.31

영문 초록

1) Puerariae Radix butanol ext. (100, 200, 400mg/kg, p.o. single treatment) alone partly showed blood pressure decreasing effect in SHRs and increasing effect of urinary volume in normal rats. 2) Cadmium nitrate (10mg/kg, s.c. single treatment) induced toxicity such as body weight decreasing effect, antidiuretic effect and muscle relaxant effect such as pull-up test, traction test and rota rod test in rats. However, Puerariae Radix butanol ext. (100, 200, 400mg/kg, p.o. single treatment) showed antidotal effects on the above and also in acute toxicity test when coadministered with both of them. 3) Cadmium nitrate (1mg/kg, s.c. 7 days consecutive treatment) did not showed toxicity in body weight change, blood pressure change, serum biochemical parameters in rats. Puerariae Radix butanol ext. (100, 200, 400mg/kg, p.o. 7 days consecutive treatment) did not also showed any antidotal effects when coadministered with both of them for 7 days.