소수성 가소제 Diethylphthalate가 Ethylcellulose 필름으로부터의 살리씰산 방출에 미치는 영향

• 영문명: Effect of Diethylphthalate on the Release of Salicylic Acid from Ethylcellulose Films
• 발행기관: 대한약학회
• 저자명: 이승룡(Seung Yong Lee) 신상철(Sang Chul Shin) 이민화(Min Hwa Lee) 심창구(Chang Koo Shim)
• 간행물 정보: 『약학회지』제28권 제3호 (1984년), 169~177쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1984.06.30

영문 초록

Release characteristics of salicylic acid from ethylcellulose(EC) films containing varying ratio of dieththylphthalate (DEP) were studied. Mathematical analysis of the release data showed that the release behavior actually conforms with the Higuchi''s diffusion-controlled model. The release rate constants(k) were independent from the film thickness and the pH of release medium, but were proportional to the concentration of salicylic acid itself. The logarithm of the release rate constant (log k) increased as the concentration of DEP was increased. In conclusion, hydrophobic plastisizer DEP seemed to be very useful in controlling release rate constant of slightly soluble drugs as like salicylic acid without changing it's release characteristics.