인도메타신의 용해도에 미치는 계면 활성제의 영향

• 영문명: Effect of Surfactants on the Solubility Properties of Indomethacin
• 발행기관: 대한약학회
• 저자명: 김경순(Kyung Soon Kim) 최영혜(Young Hye Choe)
• 간행물 정보: 『약학회지』제28권 제3호 (1984년), 161~167쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1984.06.30

영문 초록

To improve the solubility properties of indomethacin, a poorly water-soluble drug, some attempts were made with surfactants, such as sodium deoxycholate, sodium laurylsulfate and polysorbate-80. The enhancement effect in solubility was found to be due to the micellar solubilization and dependent on the concentration of surfactants, pH and temperature. The mechanism of interaction was suggested to be attributed to the formation of mixed micelles between the drug and solubilizers.