개의 신내 혈류에 미치는 Dopamine의 영향

• 영문명: Influence of Dopamine on Intrarenal Blood Flow in Dog
• 발행기관: 대한약학회
• 저자명: 고석태(Suk Tai Ko) 강호연(Ho Youn Kang)
• 간행물 정보: 『약학회지』제28권 제3호 (1984년), 149~160쪽, 전체 12쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1984.06.30

영문 초록

In order to certify the diuretic mechanism of dopamine, this study was performed in dog. The following results were obtained. Dopamine, when given intravenously, produced diuresis, and increased glomerular filtration rate(GFR), renal plasma flow(RPF), and amount of sodium excreted in urine. When infused directly into a renal artery, dopamine elicited a marked diuresis confined only to the infused side, with concomitant rises in osmolar clearance and sodium excretion as well as a slight increase in free water clearance. Simultaneously total renal plasma flow and medullary plasma flow increased markedly with a increase of glomerular filtration rate and renal plasma flow. Medullary concentration gradient of sodium also markedly lowered in the infused kidney. These changes were not observed during mannitol diuresis and renal action of dopamine were not apparent in dog pretreated with haloperidol. From the above experimental results, it is thought that dopamine, when given into a vein or infused directly into a renal artery, induces diuresis, and the mechanism of its action is due to dual actions which are hemodynamic effect along with glomerular filtration rate, and the increased response in the medullary blood flow.