alpha-Diethylaminoacetophenone의 시안화칼륨과 탄산암모늄과의 반응 메카니즘 연구(II)

• 영문명: Reaction Mechanism of alpha-Diethylaminoacetophenone with Potassium Cyanide and Ammonium Cabonate(II)
• 발행기관: 대한약학회
• 저자명: 권순경(Soon Kyoung Kwon) 조정혁(Jung Hyuck Cho)
• 간행물 정보: 『약학회지』제23권 제3&4호 (1979년), 167~171쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1979.12.30

영문 초록

It is knwon that in the reaction of a-diethylaminoacetophenone with potassium cyanide and ammonium carbonate in dilute alcohol solution, 5-phenylhydantoin is formed. In this study the mechanism of the reaction by which diethylaminomethyl group is eliminated, was investigated with applying GC/MS-system. From the fragmentation pattern of mass spectrum of the unknwon compound, which has mol peak 112, it was identified as diethylaminoacetonitrile. According to our GC/MS study of the reaction mixture, it seems likely that diethylaminomethyl group is eliminated neither through the alkali degradation of alpha-diethylaminoacetophenone to aldehyde nor after the anticipated hydantoin formation. But it is believed that in the course of ring formation through an unidentified mechanism diethylaminomethyl group is eliminated.