합성수지 용기가 FAD 수용액의 안정성에 미치는 영향

• 영문명: Effect of Synthetic Resin Container on the Stability of FAD Solution
• 발행기관: 대한약학회
• 저자명: 이계주(Gye Ju Rhee) 유병설(Byung Sul Yu)
• 간행물 정보: 『약학회지』제23권 제3&4호 (1979년), 147~152쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1979.12.30

영문 초록

Experiments were carried out to nvestigate for the interaction between FAD solution and synthetic resin containers made of polyvinylchloride(PVC), polyethylene(PE), and polycarbonate(PC), and for the effect of glycyrrhizine or malic acid on stabilization of FAD in aqueous solution by accelerated stability analysis. Analysis of FAD was determined by means of spectrometer and by separating by paper chromatography and metal ions were detected by atomic absorption spectrophotometer, which were extracted from containers by means of Food and Additive Regulation Standard. The thermal decomposition of FAD in aqueous solution was pseudo first order reaction and it was inhibited by adding glycyrrhizine or malic into the solution. PVC, PE and PC containers accelerated the decomposition of FAD in solution. It is assumed that bivalent heavy metals in resin containers may catalize the hydrolysis of FAD. The metals detected from tliecontainers were Ca, Zn, Cu, Fe, Ph and Cd. And the total amounts of detected metals from PVC were 6.2mcg/cm2, PE,5.5mcg/cm2, and PC, 2.7mcg/cm2 which were proportional to the rate constant of FAD decomposition in aqueous solution.