강황 유래 Curcumin의 Rho-kinase 억제를 통한 혈관이완작용

• 영문명: Effect of Curcuma Longa Derived-curcumin on Vascular Tension
• 발행기관: 대한약학회
• 저자명: 제현동
• 간행물 정보: 『약학회지』제57권 제5호 (2013년), 376~381쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.10.31

영문 초록

The present study was undertaken to investigate the influence of curcumin on vascular smooth muscle con- tractility and to determine the mechanism involved. We hypothesized that curcumin, the primary ingredient of Curcuma longa, plays a role in vascular relaxation through inhibition of Rho-kinase in rat aortae. Denuded arterial rings from male Sprague-Dawley rats were used and isometric tensions were recorded using a computerized data acquisition system. Inter- estingly, curcumin inhibited fluoride-induced contraction but didn't inhibit phorbol ester-induced contraction suggesting that additional pathways different from endothelial nitric oxide synthesis might be involved in the vasorelaxation. Furthermore, curcumin significantly inhibited fluoride-induced increases in pMYPT1 levels. On the other hand, it didn’t significantly inhibit phorbol ester-induced increases in pERK1/2 levels suggesting the mechanism involving inhibition of fluoride-induced MYPT1 phosphorylation. This study provides evidence that curcumin induces vascular relaxation through inhibition of Rho- kinase in rat aortae.

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키워드

curcumin endothelium fluoride MYPT1 phorbol ester Rho-kinase vasoconstriction