RBL-2H3 세포에서 Cyanidin-3-glucoside의 Th2 사이토카인 발현 억제 효과

• 영문명: Suppressive Effects of Cyanidin-3-glucoside on Th2 Cytokines Production in RBL-2H3 Cells
• 발행기관: 대한약학회
• 저자명: 정화현 윤수정 표명윤
• 간행물 정보: 『약학회지』제57권 제5호 (2013년), 309~315쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.10.31

영문 초록

Cyanidin-3-glucoside (C3G), an anthocyanin, is one of the most widespread dietary flavonoids. We investigated the effects of C3G in PMA/ionomycin (PI)-induced RBL-2H3 cells. C3G inhibited the production of IL-4 and IL-13 and also decreased the level of mRNA in a dose-dependent manner. Furthermore, western blot analysis implied that C3G down-reg- ulated the protein level of c-Jun, NF-ATc1 and NF-κB but not c-Fos. Taken together, we suggest that C3G may have sup- pressive effects on Th2 cytokines and will be studied further to develop as functional foods that help alleviate allergy symptoms.

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고찰 및 결론

감사의 말씀

참고문헌

키워드

cyanidin-3-glucoside IL-4 IL-13 RBL-2H3 cells antiallergy