랫드를 이용한 헛개나무과병 열수추출물 투여가 운동에 의한 피로회복과 운동수행능력에 미치는 기전 규명

• 영문명: The Effects of Hovenia dulcis Fruit Hot Water Extracts on Anti-fatigue and Improvement of the Exercise Performance in SD Rats
• 발행기관: 대한약학회
• 저자명: 나천수 김희경 김진범 노현정 엄나나 노혜지 나대승 동미숙 홍철이
• 간행물 정보: 『약학회지』제57권 제5호 (2013년), 348~356쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.10.31

영문 초록

The present study investigated the effects of Hovenia Dulcis (HD) fruit extract powder on the improvement of physical activity, especially exercise capacity. Forty mice were divided into 4 groups including normal controls, negative controls, 100 (HD-100) and 200 (HD-200) mg/kg HD fruit extract powder groups for 5-times exercises using treadmill. Nor- mal control did not performed treadmill running but others did 5-times for 10 days. HD fruit extract powders were admin- istrated orally one-times per day for 10 days before treadmill exercise and normal and negative controls were fed with excipient water. After 5-times exercise, blood biochemical analysis showed that aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatine phosphokinase (CK) activities and blood lactate concentration were statistically increased in negative controls than in normal controls. They were decreased in HD fruit extract powder groups, compared with negative controls. These results were considered as the effects of HD fruit extract powders on reduced tissue damages during exercise. Other measured indices did not reveal remarkable differences. All together, these results suggest that HD fruit extract powders may enhance the exercise performance by recovering the exercise-fatigue via blood lactate con- centration by reducing blood LDH activity and via reduction of blood CK and AST activity.

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키워드

Hovenia Dulcis Thunb fruit extract running exercise LDH, lactate CK