랫드에서 향부자 추출물의 13주 반복 경구투여 독성평가

• 영문명: Toxicity Assessment of Cyperi rhizoma Aqueous Extract Orally Administered to Rats for 13 Consecutive Weeks
• 발행기관: 대한약학회
• 저자명: 한소리 한형윤 박희진 민병선 정문구 문경식 정자영 노항식 석지현 김상겸
• 간행물 정보: 『약학회지』제57권 제4호 (2013년), 258~264쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.08.31

영문 초록

Herbal medicine has been traditionally used in Asian countries for a long time. Many pharmacological effects are identified in the herbs and these herbs are believed to be safe for human. However, the safety or adverse effect of some traditional herbal medicines has not been established. We have chosen Cyperi rhizoma based on the Korea Herbal Phar- macopoeia and which have been widely used for an anti-inflammatory effect in Korea. The object of the study was to eval- uate safety of Cyperi rhizoma in rats. The aqueous extract of Cyperi rhizoma was prepared according to the standard hot water extraction method of the Korea Pharmacopoeia. In the sub-chronic study, the aqueous extract of Cyperi rhizoma was orally administered once daily as 0, 125, 250, 500, 1000 and 2000 mg/kg/day to male and female F344 rats for 13 weeks. There were no treatment related abnormalities in mortality, clinical signs, food consumption, ophthalmologic examination, hematology, serum chemistry, urinalysis, gross observation, organ weight and histopathologic examination. In conclusion, The NOAEL (No Observed Adverse Effect Level) for Cyperi rhizoma aqueous extract was determined as more than 2000 mg/kg/day in the present experimental condition.

목차

실험방법

실험결과 및 고찰

결 론

감사의 말씀

참고문헌

키워드

toxicity Cyperi rhizoma NOAEL