노인 특발성 렘수면행동장애 환자에서 보이는 자율신경증상과 그 관련 요인

• 영문명: Autonomic Symptoms and Their Associated Factors in Elderly Idiopathic REM Sleep Behavior Disorder Patients
• 발행기관: 대한노인정신의학회
• 저자명: 고창민(Chang Min Go) 강석훈(Suk Hoon Kang) 최진희(Jin Hee Choi) 정혜경(Hae Gyung Chung) 김태용(Tae Yong Kim) 소형석(Hyungseok So)
• 간행물 정보: 『노인정신의학』노인정신의학 제17권 제2호, 86~91쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2013.12.31

영문 초록

Objectives：Idiopathic REM sleep behavior disorder (RBD) is by far the strongest clinical predictor of neurodegenerative disease available. Several potential early diagnostic markers of neurodegenerative disease including autonomic symptoms have been proposed, but they have generally not been tested in presymptomatic neurodegenerative disease. So the authors investigated autonomic symptoms and their associated factors in idiopathic RBD patients. Methods：52 idiopathic RBD patients and 52 controls participated in the study. Autonomic symptoms were evaluated by applying the unified multiple system atrophy rating scale (UMSARS) and measuring orthostatic systolic blood pressure drop. Results：Idiopathic RBD patients showed significantly higher UMSARS subscale scores and sharper drop of orthostatic systolic blood pressure than controls. In multiple linear regression analysis, all autonomic symptoms and measured orthostatic systolic blood pressure drop were associated with RBD. In addition, orthostatic symptoms were associated with medication and age, urinary function was associated with benign prostatic hyperplasia, and measured orthostatic systolic blood pressure drop was associated with hypertension. Conclusion：In this study, idiopathic RBD patients showed more autonomic symptoms than controls. However, other autonomic symptoms-related factors also influenced some autonomic symptoms. Prospective studies should be performed to evaluate autonomic symptoms as a potential predictor of neurodegenerative diseases.

목차

Abstract

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키워드

렘수면행동장애 자율신경증상 신경퇴행성 질환 REM sleep behavior disorder Autonomic symptoms Neurodegenerative disease