알츠하이머병에서 초조/공격성과 신경해부학적 영역의 연관성

• 영문명: Neuroanatomical Correlation of Agitation/Aggression in Alzheimer’s Disease
• 발행기관: 대한노인정신의학회
• 저자명: 정민수(Min Soo Jung) 이영민(Young Min Lee) 박제민(Je Min Park) 이병대(Byung Dae Lee) 문은수(Eun Soo Moon) 정희정(Hee Jeong Jeong)
• 간행물 정보: 『노인정신의학』노인정신의학 제17권 제2호, 69~73쪽, 전체 4쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2013.12.31

영문 초록

Objectives：The aim of this study is to identify the association between agitation/aggression and atrophy in specific brain areas in Alzheimer’s disease (AD). Methods：Fifty six patients with mild or moderate AD participated in this study. Cognitive function was measured using the Korean version of the Mini-Mental State Examination (K-MMSE), and Clinical Dementia Rating (CDR). Agitation/aggression symptoms were measured using the Korean version of the Neuropsychiatric Inventory (K-NPI). Atrophies of brain were analyzed using Voxel Based Morphometry (VBM). Results：Higher scores of agitation/aggression were correlated with the atrophy of left middle temporal, left fusiform, right middle temporal, left inferior temporal, right inferior temporal, left superior temporal, left middle occipital, right orbitofrontal, right superior frontal, left angular and right middle frontal gyrus (p＜0.001, uncorrected for multiple comparisons, extent threshold=200 voxel). Conclusion：Agitation/aggression was correlated with specific neuroanatomical changes in mild or moderate AD.

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키워드

초조 공격성 신경해부학 알츠하이머병 복셀기준형태분석 Agitaion Aggression Neuroanatomy Alzheimer’s disease Voxel based morphometry