동물실험에서의 뇌 염증과 간질

• 영문명: Brain Inflammation and Epilepsy in Experimental Animals
• 발행기관: 대한소아신경학회
• 저자명: 권영세(Young Se Kwon)
• 간행물 정보: 『Annals of Child Neurology(구 대한소아신경학회지)』대한소아신경학회지 제17권 제1호, 1~9쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2009.05.30

영문 초록

In epilepsy, there have been increasing experimental reports on the interaction between seizures and inflammation. Proinflammatory cytokines such as interleukin-1β, tumor necrosis factor-α, and interleukin-6 are rapidly increased after seizure was induced in experimental rodents. Preexisting inflammation enhances vulnerability of hippocampal neurons to status epilepticus, resulting in neuronal injury in the developing brain. Although too little is known about the role of inflammation in brain with seizures, actions of anti-inflammatory drugs, and how neuroprotection would be produced, increasing evidence has been presented that multiple mechanisms may underlie neuronal injury following inflammation-exacerbated status epilepticus. In this article will be reviewed the experimental studies for the role of brain inflammation in epilepsy.

목차

서론

본론

결론

References

Abstract

키워드

Epilepsy Inflammation Antiinflammatory drug