학술논문
Effect of Low-Intensity Transcranial Focused Ultrasound Stimulation in Patients With Major Depressive Disorder: A Randomized, Double-Blind, Sham-Controlled Clinical Trial
이용수 0
- 영문명
- 발행기관
- 대한신경정신의학회
- 저자명
- Jooyoung Oh
- 간행물 정보
- 『Psychiatry Investigation』제21권 제8호, 885~896쪽, 전체 12쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2024.08.31
4,240원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
Objective Low-intensity transcranial focused ultrasound (tFUS) has emerged as a promising non-invasive brain stimulation modality with high spatial selectivity and the ability to reach deep brain areas. The present study aimed to investigate the safety and effectiveness of low-intensity tFUS in treating major depressive disorder.
Methods Participants were recruited in an outpatient clinic and randomly assigned to either the verum tFUS or sham stimulation group. The intervention group received six sessions of tFUS stimulation to the left dorsolateral prefrontal cortex over two weeks. Neuropsycho-logical assessments were conducted before and after the sessions. Resting-state functional magnetic resonance imaging (rsfMRI) was also performed to evaluate changes in functional connectivity (FC). The primary outcome measure was the change in depressive symptoms, assessed with the Montgomery–Åsberg Depression Rating Scale (MADRS).
Results The tFUS stimulation sessions were well tolerated without any undesirable side effects. The analysis revealed a significant main effect of session sequence on the MADRS scores and significant interactions between the session sequences and groups. The rsfMRI anal-ysis showed a higher FC correlation between the right superior part of the subgenual anterior cingulate cortex (sgACC) and several oth-er brain regions in the verum group compared with the sham group.
Conclusion Our results reveal that tFUS stimulation clinically improved MADRS scores with network-level modulation of a sgACC subregion. This randomized, sham-controlled clinical trial, the first study of its kind, demonstrated the safety and probable efficacy of tFUS stimulation for the treatment of depression.
영문 초록
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
키워드
해당간행물 수록 논문
- The Association Between Prolactin Levels and Cognitive Function in Female Patients With Severe Mental Disorders
- Characteristics of Sleep Disturbance and Comparison Across Three Waves of the COVID-19 Pandemic Among Healthcare Workers
- The Different Associations of White Matter Hyperintensities With Severity of Dementia and Cognitive Impairment According to the Distance From the Lateral Ventricular Surface in Patients With Alzheimer’s Disease
- Development of a Standardized Suicide Prevention Program for Gatekeeper Intervention in Korea (Suicide CARE Version 2.0) to Prevent Adolescent Suicide: Version for Teachers
- Viral Anxiety, Reassurance-Seeking Behavior, and Depression Mediate the Influence of Dysfunctional Self-Focus on Preoccupation With COVID-19 Among Infected Cases
- Herbal and Natural Supplements for Improving Sleep: A Literature Review
- Exploring the Relationships Between Antipsychotic Dosage and Voice Characteristics in Relation to Extrapyramidal Symptoms
- Sleep Inertia and Its Associates in Shift and Non-Shift Workers
- Using Deep Learning Techniques as an Attempt to Create the Most Cost-Effective Screening Tool for Cognitive Decline
- “Food for Thought”: Improving Cognition in People With Schizophrenia
- Clinical Utility of Impact of Event Scale–Revised for Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition Posttraumatic Stress Disorder
- Simultaneous Utilization of Mood Disorder Questionnaire and Bipolar Spectrum Diagnostic Scale for Machine Learning-Based Classification of Patients With Bipolar Disorders and Depressive Disorders
- Effect of Low-Intensity Transcranial Focused Ultrasound Stimulation in Patients With Major Depressive Disorder: A Randomized, Double-Blind, Sham-Controlled Clinical Trial
- Daily Self-Monitoring and Feedback of Circadian Rhythm Measures in Major Depression and Bipolar Disorder Using Wearable Devices and Smartphones–The Circadian Rhythm for Mood (CRM®) Trial Protocol: A Randomized Sham Controlled Double-Blind Trial
참고문헌
관련논문
의약학 > 정신과학분야 BEST
- 한국판 세계보건기구 삶의 질 간편형 척도 (WHOQOL-BREF)의 개발
- 청소년 도박 실태 및 치료방법 고찰
- 그림책을 활용한 집단놀이치료 프로그램과 경계선 지능 아동의 사회성 향상에 관한 사례연구
의약학 > 정신과학분야 NEW
- Managing Circadian Rhythms: A Key to Enhancing Mental Health in College Students
- Impact of COVID-19 Infection and Related Social Concerns on Depressive Symptoms: Mediating Effects of Negative Changes in Daily Life and Moderating Effects of Age and Gender
- Evaluating the Longitudinal Efficacy of Suicide CARE (a Korean Standard Gatekeeper Training Program) in a General Community Sample: A Randomized Controlled Trial
최근 이용한 논문
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!