학술논문
The Association Between Prolactin Levels and Cognitive Function in Female Patients With Severe Mental Disorders
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- 영문명
- 발행기관
- 대한신경정신의학회
- 저자명
- Yichong Xu
- 간행물 정보
- 『Psychiatry Investigation』제21권 제8호, 832~837쪽, 전체 6쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2024.08.31
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국문 초록
Objective Cognition impairments are considered as a fundamental characteristic of severe mental disorders (SMD). Recent studies suggest that hyperprolactinemia may exert a detrimental influence on cognitive performance in patients with SMD. The objective of this study was to investigate the correlation between serum prolactin levels and cognitive function in female individuals diagnosed with SMD.
Methods We conducted a study on 294 patients with SMD and 195 healthy controls, aged between 14 to 55 years old. Cognitive func-tion was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), while prolactin levels were measured in serum. Descriptive analysis and comparative analysis were performed to compare cognitive function and prolactin levels between groups, and linear regression models were used to explore the relationship between prolactin and cognitive function.
Results Compared to the healthy control, individuals with SMD exhibited significantly higher levels of prolactin, while scoring lower on RBANS total and every index scores. Furthermore, a negative association between prolactin levels and cognitive function (RBANS total index score, attention, and delayed memory) was observed in SMD patients. Importantly, this inverse correlation between prolactin and cognition function (RBANS total index score, total scale score, and attention) persisted in patients who were not taking medications that could potentially influence serum prolactin levels.
Conclusion Our study reveals a significant correlation between elevated prolactin levels and cognitive impairment in female patients with SMD, underscoring the importance of monitoring prolactin levels in order to prevent cognitive deterioration among female SMD patients.
영문 초록
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
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