학술논문
The Different Associations of White Matter Hyperintensities With Severity of Dementia and Cognitive Impairment According to the Distance From the Lateral Ventricular Surface in Patients With Alzheimer’s Disease
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- 영문명
- 발행기관
- 대한신경정신의학회
- 저자명
- Hyun Ju Yang
- 간행물 정보
- 『Psychiatry Investigation』제21권 제8호, 850~859쪽, 전체 10쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2024.08.31
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국문 초록
Objective White matter hyperintensities (WMH) are common among the elderly. Although WMH play a key role in lowering the threshold for the clinical expression of dementia in Alzheimer’s disease (AD)-related pathology, the clinical significance of their location is not fully understood. This study aimed to investigate the association between WMH and cognitive function according to the location of WMH in AD.
Methods Subjects underwent clinical evaluations including volumetric brain magnetic resonance imaging study and neuropsychologi-cal tests using the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet. WMH were calcu-lated using automated quantification method. According to the distance from the lateral ventricular surface, WMH within 3 mm, WMH within 3–13 mm, and WMH over 13 mm were classified as juxtaventricular WMH (JVWMH), periventricular WMH (PVWMH), and deep WMH (DWMH), respectively.
Results Total WMH volume was associated with poor performance in categorical verbal fluency test (β=-0.197, p=0.035). JVWMH volume was associated with poor performances on categorical verbal fluency test (β=-0.201, p=0.032) and forward digit span test (β= -0.250, p=0.012). PVWMH volume was associated with poor performances on categorical verbal fluency test (β=-0.185, p=0.042) and word list memory test (β=-0.165, p=0.042), whereas DWMH volume showed no association with cognitive tests. PVWMH volume were also related to Clinical Dementia Rating Scale Sum of Boxes score (β=0.180, p=0.026).
Conclusion WMH appear to exhibit different associations with the severity of dementia and cognitive impairment according to the distance from ventricle surface in AD.
영문 초록
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
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