The role of 27-hydroxycholesterol in meta-inflammation

• 발행기관: 대한생리학회-대한약리학회
• 저자명: Yonghae Son Eunbeen Choi Yujin Hwang Koanhoi Kim
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제28권 제2호, 107~112쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2024.03.01

국문 초록

27-Hydroxycholesterol (27OHChol), a prominent cholesterol metabolite present in the bloodstream and peripheral tissues, is a kind of immune oxysterol that elicits immune response. Recent research indicates the involvement of 27OHChol in metabolic inflammation (meta-inflammation) characterized by chronic responses as-sociated with metabolic irregularities. 27OHChol activates monocytic cells such that they secrete pro-inflammatory cytokines and chemokines, and increase the expres-sion of cell surface molecules such as pattern-recognition receptors that play key roles in immune cell-cell communication and sensing metabolism-associated dan-ger signals. Levels of 27OHChol increase when cholesterol metabolism is disrupted, and the resulting inflammatory responses can contribute to the development and complications of metabolic syndrome, including obesity, insulin resistance, and car-diovascular diseases. Since 27OHChol can induce chronic immune response by acti-vating monocyte-macrophage lineage cells that play a crucial role in meta-inflamma-tion, it is essential to understand the 27OHChol-induced inflammatory responses to unravel the roles and mechanisms of action of this cholesterol metabolite in chronic metabolic disorders.

목차

INTRODUCTION

27OHChol AND CYTOKINES/CHEMOKINES

27OHChol AND PATTERN RECOGNITION RECEPTORS

CONCLUSION AND PROSPECTS

키워드

Atherosclerosis Meta-inflammation Monocytes/Macrophages Obesity 27-Hydroxycholesterol