학술논문
Impact of Intolerance of Uncertainty on Brain Structural Changes in Panic Disorder
이용수 4
- 영문명
- 발행기관
- 대한신경정신의학회
- 저자명
- Sungjun Ahn Sang-Hyuk Lee Kang Soo Lee
- 간행물 정보
- 『Psychiatry Investigation』제20권 제11호, 1069~1076쪽, 전체 8쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2023.11.21
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국문 초록
Objective
This study investigated the impact of intolerance of uncertainty (IU) on structural changes in the brain and symptom severity in patients with panic disorder.
Methods
This study included 90 participants diagnosed with panic disorder. The IU Scale, Panic Disorder Severity Scale (PDSS), Beck Depression Inventory-II (BDI-II), Penn State Worry Questionnaire (PSWQ), Self-Forgiveness Scale (SFS), and Short Form 36 Health Survey (SF) were used. A voxel-wise correlation analysis was conducted to investigate the structural differences in the gray matter.
Results
As IU increased, the cortical thickness of the right lingual gyrus decreased significantly, while the gray matter volume of the right pars triangularis increased. The cortical thickness of the right lingual gyrus showed a significant negative correlation with the BDI-II score and a positive correlation with the SFS. Additionally, the gray matter volume of the right pars triangularis was positively correlated with the PDSS, PSWQ, and BDI-II scores and negatively correlated with the mental health domain of the SF.
Conclusion
According to our findings, elevated IU in participants with panic disorder was associated with cortical thinning in the lingual gyrus and increased gray matter volume in the pars triangularis. These structural alterations may also have an impact on perceived quality of life, as well as high levels of depression and anxiety.
영문 초록
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
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