미세먼지 PM10에 노출된 RAW264.7 세포에 대한 해당화 추출물의 항염증 활성

• 영문명: Anti-inflammatory effects of Rosa rugosa extracts in RAW264.7 cells exposed to particulate matter (PM10)
• 발행기관: (사)한국식물생명공학회
• 저자명: 안민아(Min-A Ahn) 현태경(Tae Kyung Hyun)
• 간행물 정보: 『Journal of Plant Biotechnology』49권 2호, 145~149쪽, 전체 5쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2022.06.30

영문 초록

Airborne fine dust (FD) particles smaller than 10 μm in diameter (PM10) are one of the major causes of air pollution in East Asia, including Korea, and have become a major contributor to respiratory and skin problems. FD inordinately promotes the production of reactive oxygen species and inflammatory response in macrophages, leading to cell damage and death. Rosa rugosa, a deciduous shrub of the Rosa genus, has been used in traditional East Asian herbal medicine to treat various illnesses. The present study investigated the anti-inflammatory effects of R. rugosa organ extracts on PM10-stimulated RAW264.7 macrophages. Compared to non-treated RAW264.7 cells, treatment with 100 µg.ml-1 PM10 resulted in increased nitric oxide (NO) production, similar to lipopolysaccharide treatment. Additionally, 100 µg/ml stem extract reduced NO production by more than 45% compared to mock treatment. Furthermore, PM10- induced expression of interleukin (IL)-1β, IL-6, inducible NO synthase, and cyclooxygenase-2 was significantly reduced by stem extract treatment, indicating that the anti-inflammatory effect of the stem extract is mediated by the inhibition of pro-inflammatory mediators in PM10- stimulated RAW 264.7 cells. These results indicate that the R. rugosa stem could be considered a natural remedy with a protective effect against inflammatory responses induced by harmful airborne dust.

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키워드

airborne fine dust inflammatory response pro-inflammatory mediators Rosa rugosa