방광의 요로상피암종에서 p27，p53，p73 단백 발현에 대한 연구

• 영문명: Expression of p27, p53, p73 protein in Urothelial Carcinoma of the Urinary Bladder
• 발행기관: 조선대학교 의학연구원
• 저자명: 이상호(Sang-Ho Lee) 류려선(Reou-Sun Ryu) 서재홍(Chae-Hong Suh)
• 간행물 정보: 『The Medical Journal of Chosun University』제34권 제1호, 37~45쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.03.31

영문 초록

The Aim of this study was to investigate the expression of p27, p53 and p73 proteins in urothelial carcinomas of the urinary bladder, and to evaluate the relationship between pathologic parameters and each protein expression level. The expression of p27, p53 and p73 proteins were studied in 21 urothelial carcinoma, high glade, 12 urothelial carcinoma, low glade, 7 urothelial carcinoma in situ, 9 cystitis cystica and 9 chronic cystitis by immunᄋhistochemistry, The positive expression of the p27, p53 and p73 protein was significantly associated with high grade and stromal invasion. Our data suggest that p27, p53 and p73 protein may be involved in the development and progression of urothelial carcinoma. In addition, p53 may be a 니seful prognostic marker for individual urothelial carcinoma patients.

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p27 p53 p73 urothelial carcinoma