유근피가 고콜레스테롤식이를 급여한 흰쥐의 지질대사에 미치는 영향

• 영문명: Effect of Ulmus davidiana var. japonica Nakai Extract on Lipid Metabolism in Rats Fed High Cholesterol Diet
• 발행기관: 조선대학교 의학연구원
• 저자명: 이미정(Mi-Jeong Lee) 하진옥(Jin-Ok Ha) 이재준(Jae-Joon Lee) 이명렬(Myung-Yul Lee)
• 간행물 정보: 『The Medical Journal of Chosun University』제34권 제1호, 26~36쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.03.31

영문 초록

Background and Objectives: This study was performed to investigate the effect of ethanol extract o f Ulmus davidiana var. japonica Nakai(UDEE) on serum and liver lipid metabolism in rats fed high cholesterol diet. Methods and Materials: Male Sprague-Dawley rats were administered 1% cholesterol and 0.25% sodium cholate to induce hypercholesterolemia. W e divided into six groups; normal diet group(NOR), high cholesterol diet group(CON), normal diet and UDEE 200 mg/kg administered group(UD1), normal diet and UDEE 400 mg/kg administered group(UD2), high cholesterol diet and UDEE 200 mg/kg administered group(UDC1), and high cholesterol diet and UDEE 400 mg/kg administered group(UDC2). Results: The growth rate and liver weight of the CON group was higher than the NOR, whereas the administered UDEE groups were gradually decreased. There was a significant increase in the activities of serum ALT, AST and ALP in CON group. The administration of UDEE decreased serum ALT, AST and ALP activities in dose dependently manners. UDEE administered groups were increased HDL-C/T-C, HDL-cholesterol and phospholipid levels, and decreased serum triglyceride, total cholesterol, free cholesterol, and LDL-cholesterol levels as compared with CON group. There were no differences in the levels of serum triglyceride, phospholipid, LDL-cholesterol, HDL-cholesterol and free cholesterol between normal diet groups. The hepatic levels of total cholesterol and triglyceride were also lower in UDEE administered groups than in CON group. Conclusion: These resuIts suggest that UDEE exerts hypocholesterolemic effect by reducing serum and liver cholesterol contents.

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키워드

Ulmus davidiana var japonica Nakai high cholesterol diet lipid profiles hypocholesterolemic effect