약물전달자로서의 세포 투과성 펩타이드

• 영문명: Cell-Penetrating Peptides as Drug Delivery Carriers
• 발행기관: 조선대학교 의학연구원
• 저자명: 신송엽(Song Yub Shin)
• 간행물 정보: 『The Medical Journal of Chosun University』제34권 제1호, 1~10쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.03.31

영문 초록

Cell-penetrating peptides (CPPs) are short peptides (IQ-27 residues in length) that are able to penetrate cell membranes and deliver large molecules and even small particles inside the cell for their biological actions. The only common feature of these peptides appears to be that they are amphipathic and net positively charged. Although the detailed mechanism by which these molecules enter cells is poorly understood, their ability to traverse the membrane into the cytoplasm has provided a new and powerful biological tool for transporting drugs across cell membranes.

목차

서 론

Protein transduction domain (PTD)-derived peptides

세포 투과 메커니즘

결론 및 전망

키워드

Cell-penetrating peptides (CPPs) Intracellular delivery Drug delivery