De novo Acute Myeloid Leukemia with JAK2 V617F

• 영문명: De novo Acute Myeloid Leukemia with JAK2 V617F: A Case Report
• 발행기관: 조선대학교 의학연구원
• 저자명: Woo Sung Kim Gyun Cheol Park Sung Ho Kang Chi Young Park Sook Jin Jang Dae Soo Moon Geon Park
• 간행물 정보: 『The Medical Journal of Chosun University』제38권 제1호, 20~22쪽, 전체 3쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.03.31

영문 초록

JAK2 V617F mutation is a common event in chronic myeloproliferative disorders. However, de novo acute myeloid leukemia with JAK2 V617F is rarely encountered. The authors report the case of a 74-year-old male with de novo acute myeloblastic leukemia without maturation (AML M1) and a JAk2 V617F heterozygotic mutation. Despite treatment with standard AML regimens, the patient died 2 months after a diagnosis of acute leukemia. This case of an AML patient with a JAK2 V617F mutation with a poor prognosis suggests that despite its rarity, a JAK2 V617F mutational study be considered for prognostic purposes in AML.

목차

Introduction

Case report

Discussion

키워드

AML M1 JAK2 V617F