Betamethasone Diproprinate/Clotrimazole 도포 후 급격히 발생한 의인성 쿠싱증후군 1예

• 영문명: A Case of Rapidly Developing Iatrogenic Cushing’s Syndrome after Short-term Application of Topical Agent of Betamethasone Diproprinate/Clotrimazole Combination Ointment
• 발행기관: 조선대학교 의학연구원
• 저자명: 소중해(Jung Hae So) 김석원(Seok Won Kim) 최영민(Young Min Choi) 배학연(Hak Yeon Bae) 김상용(Sang Yong Kim) 김진화(Jin
• 간행물 정보: 『The Medical Journal of Chosun University』제38권 제1호, 42~45쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.03.31

영문 초록

Demacort^？？ is mixture of betamethasone (high-potency corticosteroid) and clotrimazole (antifungal agent), an inhibitor of CYP3A4, which can inhibit the metabolism of betamethasone. Interaction of these drugs may result in decreased clearance of betamethasone and increased risk for adverse events such as iatrogenic Cushing s syndrome. A 26-year-old female was admitted to the hospital due to rapid weight gain after application of Demacort^？？. During a period of one month, she showed weight gain of 30 kg and developed several Cushingoid appearances. The result of an overnight dexamethasone suppression test was negative, thus, endogenous Cushing s syndrome was ruled out. A negative cortisol response was observed for the rapid ACTH stimulation test; therefore, we made a diagnosis of iatrogenic Cushing’s syndrome combined with additional secondary adrenal insufficiency.

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키워드

Glucocorticoid hypersensitivity Iatrogenic cushing s syndrome Topical glucocorticoid