알츠하이머병 환자에서 해마 위축과 정신병적 증상

• 영문명: Hippocampal Atrophy and Psychotic Symptoms in Patients with Alzheimer’s Disease
• 발행기관: 대한신경정신의학회
• 저자명: 정희정(Hee Jeong Jeong)이영민(Young Min Lee) 박제민(Je Min Park) 이병대(Byung Dae Lee) 문은수(Eun Soo Moon) 김수연(Soo
• 간행물 정보: 『신경정신의학』제57권 제3호, 261~265쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2018.08.31

영문 초록

Objectives This study examined the difference in the volume or thickness of the medial temporal lobe between Alzheimer’s disease patients with psychosis (AD+P) and those without psychosis (AD-P). Methods Overall, 31 AD+P patients and 29 AD-P patients were included from the Memory impairment clinics of Pusan National University Hospital in Korea. AD+P was diagnosed according to Jeste and Finkel’s proposed diagnostic criteria for psychosis of Alzheimer’s disease. AD-P included AD patients with no psychotic symptoms during a 5-year follow-up period. Medial temporal volume or thickness was measured by 3-tesla MRI and freesufer analysis. Analysis of variance was used to examine the difference in the volume or thickness of medial temporal lobe between AP+P and AD-P after controlling for age, gender, education years, Clinical Dementia Rating scale-Sum of Box, and total intracranial volume. Results The hippocampal volume in AD+P was smaller than that in AD-P. Conclusion These findings suggest that AD+P is associated with a reduced hippocampal volume.

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키워드

Alzheimer’s disease Psychotic symptoms Medial temporal lobe Hippocampus