Glucose가 alloxan 독성(毒性) 및 alloxan 투여가토(投與家兎)의 간대사(肝代謝)에 미치는 영향(影響)에 대(對)하여

• 영문명: Influences of glucose on the alloxan toxicity to the mice and on the metabolism of the rabbits treated with alloxan
• 발행기관: 대한약리학회
• 저자명: 김형진(Kim, Hyung-Zin) 박재헌(Park, Zae-Heun) 김규호(Kim, Kyu-Ho) 임한영(Lim, Han-Young)
• 간행물 정보: 『대한약리학잡지』제5권 제1호, 45~50쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1969.06.30

영문 초록

Alloxan is a well known diabetogenic agent which destroys the beta-cell of the Langerhan s islet. The authors investigated the influence of the repeated infusion of glucose solution upon the toxicity of alloxan in the mice. The effects of glucose on the blood sugar content and the serum transaminase (S-GOT and S-GPT) activities in the rabbits treated with alloxan were also observed. The results were as follows: 1. The LD₅₀ of alloxan in mice showed a slight decrease by pretreatment with glucose for one or two weeks. 2. The elevated blood sugar level in rabbits induced by alloxan shelved a significant fall for the first 3 days by pretreatment with glucose. 3. The increased serum transaminase activities in rabbits induced by alloxan decreased for the first 3 days by pretreatment with glucose.