인삼(人蔘) Saponin 이 Morphine 에 의(依)한 Rat 대뇌피질절편(大腦皮質切片) 산소소비양(酸素消費量) 및 Na+, K+ 소장(消長)에 미치는 영향(影響)

• 영문명: The Effect of Ginseng Saponin on Morphine Action of Qo₂ and Na, K content in Cerebral Cortex Slices of Rat
• 발행기관: 대한약리학회
• 저자명: 박찬웅(Park, Chan-Woong)
• 간행물 정보: 『대한약리학잡지』제5권 제1호, 29~34쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1969.06.30

영문 초록

The effects of Ginseng saponin on respiration and Na⁺, K⁺ content of rat cerebral cortex slices were investigated to determine the action of Ginseng saponin on brain cortex at cellular level. There are many reports for the study of Ginseng on central stimulatory action in experimental animals. The electrical stimulation of slices of cortex causes a loss of potassium. And the respiration is needed to maintain a supply of energy for active cation transport. The reduction in Qo₂ is a consequence of primary cessation of active cation transport. Ginseng saponin stimulated respiration which was depressed by Morphine. But there was no significant change of electrolyte. It is suggested that the Ginseng saponin act rather on metabolic process than neural excitatory mechanism in vitro.