유황오리로부터 항종양 활성 성분의 분리 및 정제

• 발행기관: 한국축산식품학회
• 저자명: 윤원호 황진용 김창한
• 간행물 정보: 『Food Science of Animal Resources』Korean Journal for Food Science of Animal Resources 제24권 제3호, 293~297쪽, 전체 5쪽
• 주제분류: 농수해양 > 식품과학
• 파일형태: PDF
• 발행일자: 2004.09.30

영문 초록

This study was carried out to investigate the antitumor activity from sulfur fed duck. The antitumor substances were crude purified by solvent extraction, silica gel column chromatography, and HPLC using C18 column. In MTT assay, the active compounds exhibited more cytotoxic activity on tumor cell lines than normal cell line. In addition of 100㎍/mL concentrations of crude purified active compounds, the growth inhibition rate of tumor cell lines was 56% (Hep-2; human larynx), 58% (KB; human epidermoid of mouth carcinoma), and 28% (MDBK; bovine normal kidney), respectively. The survival rate of clonogenic assay was 26% in Hep-2 and 28% in KB at 200㎍/mL.

키워드

sulfur fed duck MTT assay clonogenic assay purification