학술논문
Sorting Nexin 17 Interacts Directly with Kinesin Superfamily KIF1BՂ Protein
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- 영문명
- Sorting Nexin 17 Interacts Directly with Kinesin Superfamily KIF1BՂ Protein
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- Dae-Hyun Seog Jin Han
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제12권 제4호, 199~204쪽, 전체 6쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2008.01.01
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국문 초록
영문 초록
KIF1BՂ is a member of the Kinesin superfamily proteins (KIFs), which are microtubule-dependent molecular motors that are involved in various intracellular organellar transport processes. KIF1BՂ is not restricted to neuronal systems, however, is widely expressed in other tissues, even though the function of KIF1BՂ is still unclear. To elucidate the KIF1BՂ-binding proteins in non-neuronal cells, we used the yeast two-hybrid system, and found a specific interaction of KIF1BՂ and the sorting nexin (SNX) 17. The C-terminal region of SNX17 is required for the binding with KIF1BՂ. SNX17 protein bound to the specific region of KIF1BՂ (813-916. aa), but not to other kinesin family members. In addition, this specific interaction was also observed in the Glutathione S-transferase pull-down assay. An antibody to SNX17 specifically co-immunoprecipitated KIF1BՂ associated with SNX17 from mouse brain extracts. These results suggest that SNX17 might be involved in the KIF1BՂ-mediated transport as a KIF1BՂ adaptor protein.
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