Oxidatvive Stress in Rat Model of Preeclampsia and Clinical Correlates

• 영문명: Oxidatvive Stress in Rat Model of Preeclampsia and Clinical Correlates
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Yuk-Jae Chang Won-Ki Lee Hyung-Gun Kim
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제11권 제3호, 129~133쪽, 전체 5쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2007.01.01

영문 초록

There are growing evidences suggesting a pivotal role of oxidative stress in the pathophysiology of preeclampsia. We investigated oxidative stress in the rat model of preeclampsia, and in clinical cases. Pregnant female rats were injected intraperitoneally with deoxycorticosterone acetate (DOCA) and given 0.9% saline as drinking water during their pregnancy. We assessed plasma F2-isoprostane (8-iso-PGF2α) and malondialdehyde (MDA) in a rat model, and the same markers in the plasma of maternal blood and fetal cord blood in pregnant women with preclampsia. Blood samples from the umbilical arteries and veins were collected separately. The concentrations of MDA were increased in the preeclampsia groups of animal and humans, compared with the control group; it was significantly increased in the umbilical artery and vein of the preeclampsia group. The concentrations of F2-isoprostane were elevated in the preeclampsia groups of animal and humans, compared with the control group, and the increase in F2-isoprostane concentration was prominent in the umbilical vein than umbilical artery of the preeclampsia group. Therefore, it appears that the placenta has an important role in the pathophysiology of preeclampsia, and the F2-isoprostanes of the umbilical vein may serve as a relatively reliable marker for ischemic/hypoxic injury to the fetus during the perinatal period.

키워드

Preeclampsia Oxidative stress Malonaldehyde F2-isoprostane Fetal cord blood