Effects of Ambroxol, S-carboxymethylcysteine, Dextromethorphan and Noscapine on Mucin Release from Airway Goblet Cells

• 영문명: Effects of Ambroxol, S-carboxymethylcysteine, Dextromethorphan and Noscapine on Mucin Release from Airway Goblet Cells
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Ho Jin Heo Hyun Jae Lee Chi Soon Yoon Seung Pyong Lim Jeong Ho Seok Un Kyo Seo Choong Jae Lee
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제9권 제6호, 323~326쪽, 전체 4쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2005.01.01

영문 초록

In the present study, we investigated whether ambroxol, S-carboxymethyl-L-cysteine, dextromethorphan and noscapine affect mucin release from airway goblet cells. Confluent primary hamster tracheal surface epithelial cells were metabolically radiolabeled and chased for 30 min in the presence of varying concentrations of the above agents to assess the effects on ³H-mucin release. Noscapine stimulated mucin release during 30 min of treatment period in a dose-dependent manner. However, ambroxol, S-carboxymethyl-L-cysteine and dextromethorphan showed no significant effect on mucin release during 30 min of treatment period. We conclude that noscapine can affect mucin release by acting on airway mucin-secreting cells.

키워드

Airway Mucin Ambroxol S-carboxymethyl-L-cysteine Dextromethorphan Noscapine