Pharmacokinetics of Dehydroevodiamine Following Intravenous Administration in Rats

• 영문명: Pharmacokinetics of Dehydroevodiamine Following Intravenous Administration in Rats
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Seong Yun Kim Chan-Soo Moon Yun-Sik Choi Sang Bok Lee
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제8권 제1호, 65~67쪽, 전체 3쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2004.01.01

영문 초록

Dehydroevodiamine (DHED) is one of the bioactive components of the Chinese herbal medicine Wu-chu-yu-tang that has been shown to produce various pharmacological effects. In the present study, we investigated the pharmacokinetics of DHED after intravenous administration of two doses (2.5 and 5 mg/kg) in anesthetized rats. The plasma concentration of DHED was measured by reverse-phase high-performance liquid chromatography with UV detection. The mean area under the curve of the time-concentration profile was 21.9 and 53.9 μgてmin/ml after the 2.5- and 5-mg/kg doses, respectively, and the volume of distribution was 1584.9 and 1580.6 ml following 2.5- and 5-mg/kg doses, respectively. Plasma concentration profiles versus time were compatible with a two-compartment model and first-order kinetics. The terminal elimination half-life was 91.8⁑16.6 min and 78.7⁑11.9 min in the dose of 2.5 and 5 mg/kg, respectively. This is the first report to study the pharmacokinetics of DHED in animals.

키워드

Dehydroevodiamine Pharmacokinetics Wu-chu-yu HPLC Intravenous injection,