Role of Stretch-Activated Channels in Stretch-Induced Changes of Electrical Activity

• 영문명: Role of Stretch-Activated Channels in Stretch-Induced Changes of Electrical Activity
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Jae Boum Youm Su-Hyun Jo Chae Hun Leem Won-Kyung Ho Yung E.
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제8권 제1호, 33~41쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2004.01.01

영문 초록

We developed a cardiac cell model to explain the phenomenon of mechano-electric feedback (MEF), based on the experimental data with rat atrial myocytes. It incorporated the activity of ion channels, pumps, exchangers, and changes of intracellular ion concentration. Changes in membrane excitability and Ca^2⁢ transients could then be calculated. In the model, the major ion channels responsible for the stretch-induced changes in electrical activity were the stretch-activated channels (SACs). The relationship between the extent of stretch and activation of SACs was formulated based on the experimental findings. Then, the effects of mechanical stretch on the electrical activity were reproduced. The shape of the action potential (AP) was significantly changed by stretch in the model simulation. The duration was decreased at initial fast phase of repolarization (AP duration at 20% repolarization level from 3.7 to 2.5 ms) and increased at late slow phase of repolarization (AP duration at 90% repolarization level from 62 to 178 ms). The resting potential was depolarized from ⁣75 to ⁣61 mV. This mathematical model of SACs may quantitatively predict changes in cardiomyocytes by mechanical stretch.

키워드

Stretch-activated channels Mechanical stretch Atrial myocyte