흰쥐의 척수에서 Cyclic Nucleotides 및 Glipizide가 Baclofen의 심혈관반응에 미치는 영향 Effects of Cyclic Nucleotides and Glipizide on the Cardiovascular Response of Baclofen in the Rats

• 영문명: Effects of Cyclic Nucleotides and Glipizide on the Cardiovascular Response of Baclofen in the Rats.
• 발행기관: 대한생리학회-대한약리학회
• 저자명: 신인철(In Chul Shin) 고현철(Hyun Chul Koh) 하지희(Ji Hee Ha)
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제1권 제6호, 647~655쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1997.01.01

영문 초록

The purpose of present study is to investigate the influence of a spinal gamma-aminobutyric acid B(GABAs) receptor on a central regulation of blood pressure(BP) and heart rate(HR)， and to define its mechanism in the spinal cord. In urethane-anesthetized， d-tubocurarine-paralyzed and artificially ventilated male Sprague-Dawley rats， intrathecal administration of drugs were carried out using injection cannula(33-gauge stainless steel) through the guide cannula(PE 10) which was inserted intrathecally at lower‘ thoracic level through the punctur‘e of a at1antooccipital membrane. Intrathecal injection of an GABAs receptor agonist， baclofen(30， 60， 100 nmol) decreased both BP and HR dose-dependently. Pretreatment with 8-bromo-cAMP(50 nmol)， a cAMP analog， or glipizide(50+ nmol) ， a ATP-sensitive K. channel blocker， attenuated the depressor and bradycardic effects of baclofen(100nmol) ， but not with 8-bromo-cGMP(50 nmol) ， a cGMP analog. These resu1ts suggest that the GABAs receptor in the spinal cord plays an inhibitory role in centr‘al cardiovascular regulation and that this depressor and bradycardic actions are mediated by the decrease of cAMP via the inhibition of adenylate cyclase and the opening of K十 channel.

키워드

Baclofen Spinal cord cAMP cGMP Glipizide Blood pressure Heart rate