PAF 길항제가 허혈성 대뇌 피질내 Nitric Oxide 합성에 미치는 영향

• 영문명: Effect of PAF Antagonists on the Nitric Oxide Synthesis in Ischemic Cerebral Cortex
• 발행기관: 대한생리학회-대한약리학회
• 저자명: 이원석(Won Suk Lee) 노순기(Soon Kee No) 박규현(Kyu Hyun Park)
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제1권 제6호, 665~672쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1997.01.01

영문 초록

This study aimed to investigate the mechanism of cerebroprotection of platelet-activating factor(PAF) antagonists in transient cerebral ischemia of rat. Right middle cerebral artery(MCA) of Sprague-Dawley rat was occluded for 2 hours using an intraluminal filament technique. After 22 hours of reperfusion, morphometrically detectable infarct was developed in the cortex and striatum identical to the territory of MCA. The infarct size was significantly reduced by PAF antagonists, BN 52021 and CV-6209, as well as an inducible nitric oxide synthase(iNOS) inhibitor aminoguanidine(1 mg/kg, i.p., respectively) administered 5 min after MCA occlusion. PAF antagonists significantly inhibited the enzymatic activities of both myeloperoxidase and iNOS in the cerebral hemisphere ipsilateral to ischemia, whereas aminoguanidine did not inhibit myeloperoxidase activity but significantly inhibited the iNOS activity. These results suggest that PAF antagonists exert a cerebroprotective effect against ischemic brain damage through inhibition of leukocyte infiltration and iNOS activity in the postischemic brain.

키워드

Cerebral ischemia PAF antagonists Nitric oxide