중추에서 혈압과 심박수 조절에 관여하는 후시상하부 콜린성 수용체의 일차적인 역할

• 영문명: Primary Role of Posterior Hypothalamic Cholinergic Receptors in Central Regulation of Blood Pressure and Heart Rate in Rats
• 발행기관: 대한생리학회-대한약리학회
• 저자명: 김성윤(Seong Yun Kim) 성기욱(Ki Wug Sung) 고현철(Hyun Chul Koh) 이상복(Sang Bok Lee)
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제1권 제6호, 639~645쪽, 전체 7쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1997.01.01

영문 초록

The purpose of the present study is to determine the role of muscarinic cholinergic receptors of posterior hypothalamus in the central blood pressure regulation when respiration is controlled. In anesthetized and artificially ventilated rats, vasodepressor response was evoked by injection of L-glutamate(10 nmol) neuroexcitatory amino acid into the posterior hypothalamic area. The injection of carbachol(0.5∼8 nmol) into the same area induced dose-dependent vasodepressor and bradycardic responses. Pretreatment with atropine(4 nmol) completely blocked the vasodepressor response to carbachol(2 nmol). In contrast, in spontaneously breathing rats, the injection of carbachol(8 nmol) into the posterior hypothalamic area induced the vasopressor and tachycardic responses. These results suggest that the muscarinic cholinergic receptors in the posterior hypothalamic area primarily play an inhibitory role in the central regulation of blood pressure and heart rate.

키워드

Posterior hypothalamus Cholinergic mechanism Blood pressure Heart rate Muscarinic receptors L-glutamate Respiration Spontaneous breathing Rat