토끼 Coronary Sinus에서의 안정막 전압에 관한 연구

• 영문명: Ionic Basis of Resting Membrane Potential in the Coronary Sinus Cells of the Rabbit
• 발행기관: 대한생리학회
• 저자명: 장진근(Chang, Jin-Keun) 엄융의(Earm, Yung-E)
• 간행물 정보: 『대한생리학회지』제20권 제2호, 184~191쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1986.12.31

영문 초록

Membrane potential of cells in the isolated rabbit coronary sinus was measured by conventional glass microelectrode and investigated the effect of [K⁺]₀ variation in control, 20 mM and Ach-containing Tyrode solution. The results obtained were as follows: 1) The resting membrane potential exposed to normal Tyrode solution containing 3 mM K⁺ was about -60 ~ -65mV. At extracellular K⁺ concentrations from 1 to 30 mM the resting Potential was reasonably well described by Goldman -Hodgkin -Katz equation on the assumption that [K⁺]₁ was 150 mM and that the ratio of membrane permeability coefficient for Na⁺ and K⁺, P_Na/P_K (α) was 0.07. 2) In 20 mM Na-Tyrode solution (replacing by equimolar Tris) the resting membrane potential was hyperpolarized by 15 to 20 mV and showed slightly deviated to depolarized direction compared to the predicted value by Goldman-Hodgkin -Katz equation. 3) In the presence of 10^-6M Ach, the resting potentials at [K⁺]₀ levels from 1 to 30 mM were well fitted with the predicted value on the assumption that P_Na/P_K was 0.0144. It could be concluded that the low resting membrane potential of coronary sinus cells reflects a relatively high ratio P_Na/P_K of about 0.07.