Vanadate가 심근막을 통한 Ca++의 유입 및 유출에 미치는 영향

• 영문명: Effects of Vanadate on the Calcium Flux of Cardiac Muscle
• 발행기관: 대한생리학회
• 저자명: 박영식(Park, Young-Shick) 안덕선(Ahn, Duck-Sun) 강두희(Kang, Doo-Hee)
• 간행물 정보: 『대한생리학회지』제20권 제2호, 175~183쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1986.12.31

영문 초록

Since it was proposed that vanadate may be an ‘ideal endogenous regulator of the Na⁺, K⁺-ATPase activity (Cantley et at, 1979), vanadate has been a subject of intensive research and a variety of its physiological effects have been described (Nechay, 1984). In isolated guinea pig heart muscle vanadate shows a positive inotropic effect on ventricular muscle, while it induces a negative inotropic effect on atrial muscle. But its underlying mechanism has not been elucidated so far. Therefore, in this study the flux rates of calcium ion into and from guinea pig heart muscle were measured to throw some light on the underlying mechanism, because those rates have been known to be closely related to the cardiac contractility and the results are summarized as follows: 1) Calcium efflux rates from the intracellular Ca⁺⁺ pool (compartment 4) of both guinea pig left atrium and right ventricle were significantly reduced by vanadate and their pool sizes were significantly increased by vanadate. 2) The magnitude of calcium influx into left atrium was reduced by vanadate, While the magnitude of calcium influx into right ventricle was not affected by vanadate. From these results, it may be concluded that the positive inotropic effect of vanadate on the ventricular muscle was due to a reduced efflux rate of calcium ion and its negative inotropic effect on atrial muscle was resulted from a reduced influx of calcium ion.