인체 적혈구막 Band 4.5 단백질의 기능적인 분자구조

• 영문명: Functional Molecular Structure of Band 4.5 Protein of Human Erythrocyte Membrane
• 발행기관: 대한생리학회
• 저자명: 하종식(Hah, Jong-Sik)
• 간행물 정보: 『대한생리학회지』제20권 제2호, 209~217쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1986.12.31

영문 초록

The functional molecular weight of band 4.5 polypeptide was measured by applying the classical target theory to radiation inactivation data of the cytochalasin B binding. Band 4.5 polypeptides purified from human erythrocyte membranes were irradiated at -45 to -50℃ with an increasing dose of 1.5 MeV electron beam, and after thawing, cytochalasin B binding activities were assayed. Each activity measured was reduced as a simple exponential function of radiation dose. D₃₇, dose appeared to be 6.7 mega rads, from which the target size (radiation sensitive mass) of band 4.5 polypeptide was calculated to be 95,500 daltons. This result with other informations available in literature suggests that band 4.5 polypeptide may exist as a dimer in human erythrocytes.