신성 고혈압 백서 심방의 심방이뇨 호르몬분비 특성

• 영문명: Characteristics of Atrial Natriuretic Peptide Release in Renal Hypertensive Rats
• 발행기관: 대한생리학회
• 저자명: 조경우(Cho, Kyung-Woo) 설경환(Seul, Kyung-Hwan) 김선희(Kim, Suhn-Hee) 설경미(Seul, Kyung-Mee) 고규영(Koh, Gou-Young
• 간행물 정보: 『대한생리학회지』제24권 제2호, 261~268쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1990.12.31

영문 초록

It has long been suggested that the cardiac atrium is a low pressure volume receptor controlling body fluid volume and blood pressure. Recently, the cardiac atrium has been found to contain a family of powerful peptides. To clarify the relationship between high blood pressure and the biologically active atrial peptides, experiments were done to define the characteristics of atrial natriuretic peptide secretion in the isolated perfused atria of renal hypertensive rats. Higher concentrations of plasma atrial natriuretic peptide and renin activity were observed in the two-kidney, one clip hypertensive rat compared to the normotensive rat. Atrial volume changes in response to pressure elevations were attenuated in hypertensive rats compared to normotensive rats. Incremental response to atrial volume changes in ANP secretion was accentuated in hypertensive rats. These date suggest that the accentuated atrial natriuretic peptide response to volume changes of hypertensive rats may be a physiological or pathphysiological adaptation to the high blood pressure and may be, at least in part, responsible for the elevated levels of plasma atrial natriuretic peptide observed in hypertensive rats.