Adenosine 유사체의 신장효과에 미치는 Adenosine 차단제의 영향

• 영문명: Receptor Specificity of Adenosine Analogs in Terms of Renal Function and Renin Release
• 발행기관: 대한생리학회
• 저자명: 윤영의(Yun, Young-Yi) 고규영(Koh, Gou-Young) 김선희(Kim, Suhn-Hee) 조경우(Cho, Kyung-Woo)
• 간행물 정보: 『대한생리학회지』제24권 제2호, 269~280쪽, 전체 12쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1990.12.31

영문 초록

The purpose of the present experiment was to determine the functional subclassification of renal adenosine receptor fer the hemdynamic, excretory and secretory functions in unanesthetized rabbits. Adenosine antagonist, 8-phenyltheophylline (8-PT) or theophylline, was infused into the left renal artery followed by an infusion of adenosine agonist, cyclohexyladenosine (CHA) or 5 -N-ethylcarboxamidoadenosine (NECA). Intrarenal arterial infusion of CHA or NECA caused decreases in urine volume, glomerular filtration rate, renal plasma flow and excreted amount of electrolytes and renin release in a dose-dependent manner. Dose-response curves in renal function by CHA or NECA was similar and shifted to the right with pretreatment of 8-PT or theophylline. No significant differences in renal response to CHA and NECA in antagonist-treated rabbits were observed. However, the decrease in renin secretion rate was not affected by the adminstration of adenosine antagonists. These results suggest that the renal effect of adenosine receptor agonists appears by way of specific adenosine receptor, but which is not functionally subclassified in the rabbit.