Vasoactive Intestinal Peptide(VIP)의 백서신장기능(白鼠腎臟機能)에 미치는 영향(影響)

• 영문명: Effect of Vasoactive Intestinal Peptide on Renal Function in Rats
• 발행기관: 대한생리학회
• 저자명: 김선희(Kim, Suhn-Hui) 조경우(Cho, Kyung-W)
• 간행물 정보: 『대한생리학회지』제16권 제2호, 159~164쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1982.12.31

영문 초록

Vasoactive intestinal peptide (VIP) found in duodenal mucosa originally has been suggested as a neurotransmitter. Its localization, however, now known, is not limited to the gastrointestinal tract, but scattered at many different kinds of tissues, smooth muscles, endocrine gland and exocrine gland as well as central and peripheral neural tissues. To investigate the effect of VIP on renal function, an experiment has been done in anesthetized male rats. The results obtained were: 1) Urinary output and creatinine clearance decreased significantly during the period of infusion of VIP, 2.0ug/rat/7minutes. 2) Urinary excretion of sodium, potassium and chloride decreased but without significance by infusion of VIP. 3) Blood pressure, systolic and diastolic, decreased by VIP administered intravenously in the period of infusion. 4) Changes of urinary output, sodium and chloride excretion was correlated with changes of creatinine clearance. The above data suggest that VIP administered intravenously can suppress the renal hemodynamics indirectly, and also decrease electrolyte excretion through its renal hemodynamic change.